Catalog Number - 85118-15P

The 85118‑15P Cogent RP C18 ABX™ UHPLC Column is engineered for maximum‑resolution analytical separations, delivering robust and reproducible performance across a wide pH range (2–12).

Featuring a bulky end‑capped C18 bonded phase on high‑purity silica, this column minimizes secondary interactions and improves peak shape for acidic, basic, and neutral analytes, especially those with very high or very low pKa values.

✅ Ideal as a USP L1 alternate for methods involving strong acids or bases

150 mm Length – Maximum Resolution for Analytical Methods

• Highest resolving power in the 4.6 mm ABX column range

• Maximizes peak capacity for complex mixtures

• Ideal for closely related compounds and difficult separations

• Preferred for final method development and validation workflows

✅ Selected when maximum separation performance is required beyond 50 mm and 100 mm columns

4.6 mm ID – Standard Analytical Platform

• Compatible with standard UHPLC systems

• Ideal for:

  • method development

  • QC and regulated laboratory workflows

Typical Flow Rate Range

• ~0.8–1.5 mL/min

✅ Provides robust, reproducible analytical performance

1.8 µm Particle – Maximum Efficiency & Performance

• Delivers ultra‑high efficiency and sharper peak shapes

• Greater peak capacity vs 3 µm columns

• Improves:

  • resolution in complex mixtures

  • performance of existing methods

✅ Ideal for:

• high‑resolution analytical workflows

• improving separation without increasing runtime excessively

⚠️ Higher backpressure → UHPLC system required

Wide pH Stability (pH 2–12) – Extreme Method Flexibility

• Designed for acidic and basic mobile phase conditions

• Enables separation of:

  • Strong acids

  • Strong bases

  • Challenging polar and neutral compounds

✅ Extends capability beyond standard C18 columns

Why Choose RP C18 ABX™ Columns

Extreme pH Ruggedness

• Stable across full pH spectrum (2–12)

• Ideal for aggressive and stability‑indicating methods

Improved Peak Shape for Acids & Bases

• Advanced end‑capping reduces secondary interactions

• Enhances analytical reproducibility and accuracy

High‑Efficiency Method Development

• Reduces solvent consumption and cost

• Improves laboratory throughput and efficiency

✅ Excellent for final analytical method optimization and validation

System & Sample Considerations

• ⚠️ Requires UHPLC system capable of high pressure operation

• Recommended sample preparation:

  • 👉 Use 0.2 µm syringe filters for proper sample preparation before injection

✅ Helps:

• Prevent column blockage

• Maintain performance and column lifetime

Typical Applications

• UHPLC and HPLC analysis

• Acidic and basic compound separations

• Pharmaceutical method development and validation

• Stability‑indicating methods

• Hydrophobic and neutral compound analysis

• Complex mixture resolution under extreme pH

Important Usage Notes

• Designed for UHPLC (high‑pressure) systems

• Suitable for extreme pH mobile phases (pH 2–12)

• Ideal for maximum‑resolution analytical workflows

• Monitor system pressure to ensure safe and stable operation